The Role of Haptoglobin and Its Genetic Polymorphism in Cancer: A Review

Acute phase response is a stereotyped innate nonspecific reaction of the body proceeding specific immune reactions. It ́s a systemic homeostatic reaction of the organism to local and or systemic disturbances caused by infections, tissue injury, trauma, immunologic disorders and neoplasias (Ron D et al 1990, Trautwein C et al 1994, Gruys E et al 2005). Proinflammatory cytokines are released at the place of tissue injury, diffuses locally and systemically to the vascular system and activates receptors on different target cells resulting in the activation of hypothalamic-pituitary-adrenal axis (HPAA), results in the production of growth hormone secretion and induces changes in the concentration of several plasma proteins (Ron D et al 1990, Trautwein C et al 1994, Gruys E et al 2005).